Post-translational modifications in embryonic cell cycle
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چکیده
منابع مشابه
Post-translational modifications in embryonic cell cycle
Development is a highly ordered process that institutes considerable changes in cell cycle structure of the different cells composing the embryo. Cell fate is decided at early stages of embryogenesis in embryonic stem cells (ESCs). These cells are derived from the inner cell mass of the primordial embryo and can give rise to all cell lineages of the 3 primary germ layers. The cell cycle of ESCs...
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The synthesis and destruction of cyclin B drives mitosis in eukaryotic cells. Cell cycle progression is also regulated at the level of cyclin B translation. In cycling extracts from Xenopus embryos, progression into M phase requires the polyadenylation-induced translation of cyclin B1 mRNA. Polyadenylation is mediated by the phosphorylation of CPEB by Aurora, a kinase whose activity oscillates ...
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Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism ...
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Detection and characterization of histone PTMs have been conducted by antibodies, Bottom Up MS, and Top Down MS. As analytical techniques, however, they are not germane to quantitative biology unless they can provide consistently reproducible data that can be used to extrapolate trends and make correlations in addition to answering questions regarding modifications singly and in combination. Hy...
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Fe-type nitrile hydratase (NHase) from Rhodococcus sp. N771 has a novel non-heme iron active center with two post-translationally modified cysteine residues, cysteine-sulfenic and -sulfinic acids. The modified residues are involved in the sequence motif, Cys-Xxx-Leu-Cys-Ser-Cys (Xxx = Ser(Fetype)/Thr(Co-type)), which is conserved among all known NHases as well as in the homologous enzyme, thioc...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2014
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.28750